I'm all set and booked for the 2009 PyCon in Chicago next month. I was unable to attend last year's event, and am looking forward to what looks like a wealth of interesting talks. If anyone is interested in meeting up, send me an email to chuck at evilchuck.com.
If you haven't decided if you are going to attend or not, I highly recommend it. It is a great place to listen to different ideas, meet great people, and learn new stuff. I hope to see you there!